Study questions B12 dementia advice
By Emma Wilkinson
Wellness reporter, BBC News
Taking vitamin B12 and folic acid supplements does not seem to cut the danger of creating dementia, state Dutch scientists.
This contradicts what has previously been recommended, they claim.
In one of the biggest researches to day, there was no difference in memory examination ratings between those who had actually taken the supplements for 2 years and those that were provided an inactive medicine.
The study was released in the diary Neurology.
B vitamins have been connecteded to Alzheimer’s for some years, and also researchers understand that greater degrees of a physical body chemical called homocysteine could raise the threat of both movements as well as alzheimer’s disease.
Vitamin B12 as well as folic acid are both known to reduced levels of homocysteine.
No safety impact
That, together with studies connecting reduced vitamin B12 as well as folic acid intake with bad memory, had actually motivated scientists to watch the supplements as a means to fend off alzheimer’s disease.
Yet in the research study of practically 3,000 individuals – with an average age of 74 – that took 400 micrograms of folic acid and 500 micrograms of vitamin B12 or a sugar pill daily, researchers found no proof of a safety effect.
All those taking part in the test had high blood levels of homocysteine, which did fall more in those taking the supplements.
Yet on four different driving tests of memory as well as believing abilities taken at the start and also end of the research, there was no beneficial effect of the supplements on performance.
The analysts did note that the supplements might a little reduce the price of decline however concluded the tiny difference they spotted could merely have been down to possibility.
Study leader Dr Rosalie Dhonukshe-Rutten, from Wageningen University in the Netherlands, claimed: “Because homocysteine levels could be lowered with folic acid and vitamin B12 supplements, the hope has actually been that taking these vitamins could likewise lower the risk of amnesia and Alzheimer’s condition.
“While the homocysteine degrees decreased by more in the team taking the B vitamins than in the team taking the inactive medicine, however there was no difference between both groups in the ratings on the thinking and also memory tests.”
Healthy human brain
Dr Eric Karran, director of research at Alzheimer’s Research UK, stated: “This huge trial contributes to previous evidence proposing that while vitamin B supplements could lower homocysteine degrees, this does not equate into enhanced memory as well as thinking in the general older populace.”
However he stated the trial did not check out folks which were currently experiencing memory decline.
Longer follow-up durations would be had to see if vitamin B12 or folic acid might decrease the extreme memory decrease linked with alzheimer’s disease, he claimed.
Dr Karran included: “Although this study calls into question the usage of vitamin B or folic acid supplements to help memory, a well balanced diet regimen is a good method to keep healthy in any way ages.
“Proof suggests that we could maintain a healthy mind for longer by keeping a healthy weight, eating a well balanced diet regimen, not cigarette smoking, staying active, consuming in moderation and keeping blood stress as well as cholesterol levels in check.”